Description
The National Center for Environmental Health (NCEH), Division of Laboratory Sciences (DLS), Newborn Screening and Molecular Biology Branch (NSMBB) is seeking a highly motivated scientist to support critical public health initiatives in newborn screening. The incumbent will contribute to the development, validation, and implementation of advanced analytical methods, with a strong emphasis on mass spectrometry-based assays and dried blood spot (DBS) technologies.
This position plays a key role in supporting national newborn screening programs through the development of high-quality reference materials, calibration systems, and analytical workflows that ensure accuracy, reliability, and standardization across laboratories.
Key Responsibilities
Analytical Method Development & Validation
Develop, optimize, and validate LC-MS/MS and related analytical methods for newborn screening biomarkers.
Troubleshoot analytical workflows and improve assay performance, sensitivity, and specificity.
Apply advanced mass spectrometry techniques, including small molecule analysis and metabolomics approaches.
Reference Materials & Quality Systems
Develop, characterize, and manufacture dried blood spot (DBS)-based quality control and proficiency testing materials.
Design and produce DBS-based calibrators to support assay standardization and accuracy.
Ensure all materials meet applicable quality and regulatory standards.
Laboratory Operations & Analysis
Perform chemical and biochemical analyses according to established protocols and project timelines.
Conduct sample preparation using techniques such as liquid-liquid extraction and solid-phase extraction.
Maintain and operate LC-MS/MS and related instrumentation.
Data Analysis & Interpretation
Analyze experimental data using statistical approaches (e.g., descriptive statistics, regression, multivariate analysis).
Interpret results and provide scientifically sound conclusions to support decision-making.
Support data management, database entry, and reporting activities.
Quality Assurance & Compliance
Participate in QA/QC activities including reagent verification, instrument validation, and review of control data.
Ensure compliance with ISO 17043, ISO 17034, CLIA, and other applicable regulatory standards.
Assist in the development and maintenance of Standard Operating Procedures (SOPs).
Collaboration & Scientific Contribution
Collaborate with multidisciplinary teams to improve methods, processes, and testing procedures.
Provide technical expertise and consultation to internal and external stakeholders.
Contribute to scientific reports, publications, and presentations.
Requirements
Minimum Qualifications
Citizenship Requirement
Applicants must be U.S. citizens.
Education
Master’s or Ph.D. in Chemistry, Biochemistry, Biology, or a related scientific field.
Experience
At least one year of specialized experience equivalent to the GS-11 level, including: Development and validation of LC-MS/MS or other analytical methods
Experience working in an ISO or CLIA-regulated laboratory environment
Statistical data analysis and interpretation
Providing technical guidance or consultation in a laboratory setting
Required Knowledge:
Strong expertise in LC-MS/MS method development and validation for small molecules
Experience with sample preparation techniques (e.g., SPE, LLE)
Familiarity with analytical software (e.g., MassLynx, Analyst, Xcalibur, MassHunter, Skyline, R, JMP, SAS, Python)
Knowledge of newborn screening workflows and biomarkers (preferred)
Strong analytical thinking and problem-solving skills
Excellent written and verbal communication skills
Ability to manage multiple priorities and meet deadlines
Ability to work both independently and collaboratively in a team environment